Cart
sales@molnova.com
Beclabuvir hydrochloride
CAS No. 958002-36-3
Beclabuvir hydrochloride( BMS791325 | BMS-791325 )
Catalog No. M16843 CAS No. 958002-36-3
Beclabuvir (BMS-791325) is a potent allosteric inhibitor of HCV NS5B polymerase with EC50 of 6 and 3 nM for genotype 1b and 1a in FRET assays, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1143 | Get Quote |
|
| 50MG | 2322 | Get Quote |
|
| 100MG | 3060 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameBeclabuvir hydrochloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionBeclabuvir (BMS-791325) is a potent allosteric inhibitor of HCV NS5B polymerase with EC50 of 6 and 3 nM for genotype 1b and 1a in FRET assays, respectively.
-
DescriptionBeclabuvir (BMS-791325) is a potent allosteric inhibitor of HCV NS5B polymerase with EC50 of 6 and 3 nM for genotype 1b and 1a in FRET assays, respectively; inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 with IC50 of <30 nM; the combination of beclabuvir with asunaprevir and daclatasvir achieves very high rates of viral eradication (about 90%) in patients infected with HCV genotype 1 in clinical trials.HCV Infection Phase 1 Discontinued.
-
In Vitro——
-
In Vivo——
-
SynonymsBMS791325 | BMS-791325
-
PathwayMicrobiology/Virology
-
TargetHCV
-
RecptorHCV
-
Research AreaInfection
-
IndicationHCV Infection
Chemical Information
-
CAS Number958002-36-3
-
Formula Weight696.304
-
Molecular FormulaC36H46ClN5O5S
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCN1CC2CCC(C1)N2C(=O)C34CC3C5=C(C=CC(=C5)OC)C6=C(C7=C(N6C4)C=C(C=C7)C(=O)NS(=O)(=O)N(C)C)C8CCCCC8.Cl
-
Chemical Name(4bS,5aR)-12-cyclohexyl-N-(N,N-dimethylsulfamoyl)-3-methoxy-5a-((1R,5S)-3-methyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-4b,5,5a,6-tetrahydrobenzo[3,4]cyclopropa[5,6]azepino[1,2-a]indole-9-carboxamide hydrochloride
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Gentles RG, et al. J Med Chem. 2014 Mar 13;57(5):1855-79.
2. Sims KD, et al. Antimicrob Agents Chemother. 2014 Jun;58(6):3496-503.
3. Everson GT, et al. Gastroenterology. 2014 Feb;146(2):420-9.
4. Pelosi LA, et al. Antimicrob Agents Chemother. 2012 Oct;56(10):5230-9.
molnova catalog
related products
-
GSK-2878175
GSK-2878175 (GSK-175, GSK-175A) is a potent, pan-genotypic, second generation HCV NS5B polymerase inhibitor with EC50 of 0.4-9.7 nM.
-
VCH-916
VCH-916 is a new nonnucleoside inhibitor of HCV NS5B polymerase.
-
CEP37440
CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).
